Dev125740 2464..2477
نویسندگان
چکیده
Neurogenesis involves deeply conserved patterning molecules, such as the proneural basic helix-loop-helix transcription factors. Sox proteins and specifically members of the SoxB and SoxC groups are anotherclassof conserved transcription factorswithan important role in neuronal fate commitment and differentiation in various species. In this study,we examine the expressionof all fiveSox genes of the nematode C. elegans and analyze the effect of null mutant alleles of all members of the SoxB and SoxC groups on nervous system development. Surprisingly, we find that, unlike in other systems, neither of the two C. elegans SoxB genes sox-2 (SoxB1) and sox-3 (SoxB2), nor the sole C. elegans SoxC gene sem-2, is broadly expressed throughout the embryonic or adult nervous system and that all three genes are mostly dispensable for embryonic neurogenesis. Instead, sox-2 is required to maintain the developmental potential of blast cells that are generated in the embryo but divide only postembryonically to give rise to differentiated neuronal cell types. Moreover, sox-2 and sox-3 have selective roles in the terminal differentiation of specific neuronal cell types. Our findings suggest that the common themes of SoxB gene function across phylogeny lie in specifying developmental potential and, later on, in selectively controlling terminal differentiation programs of specific neuron types, but not in broadly controlling neurogenesis.
منابع مشابه
The tubulin inhibitor MG-2477 induces autophagy-regulated cell death, ROS accumulation and activation of FOXO3 in neuroblastoma
Neuroblastoma is the most frequent extra-cranial solid tumor in children with still high mortality in stage M. Here we studied the tubulin-inhibitor MG-2477 as a possible therapeutic agent for neuroblastoma therapy and uncovered that MG-2477 induces death in neuroblastoma cells independent of PKB-activation status and stage. MG-2477 triggers within 30 minutes extensive autophagosome-formation t...
متن کاملIntramuscular Sarcocystis in two beluga whales and an Atlantic white-sided dolphin from the St. Lawrence estuary, Quebec, Canada.
2. Dubey JP: 1988, Lesions in sheep inoculated with Sarcocystis tenella sporocysts from canine feces. Vet Parasitol 26:237-252. 3. Dubey JP, Lindsay DS, Speer CA, et al.: 1988, Sarcocystis arieticanis and other Sarcocystis species in sheep in the United States. J Parasitol 74: 1033-1038. 4. Dubey JP, Speer CA, Callis G, Blixt JA: 1982, Development of the sheep-canid cycle of Sarcocystis tenella...
متن کاملAn association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients.
PURPOSE We examined the pattern of single-nucleotide polymorphisms (SNPs) of gemcitabine metabolism-related and target genes in breast cancer patients and evaluated their association with drug response or toxicity. PATIENTS AND METHODS SNPs in deoxycytidine kinase (dCK), deoxycytidine monophosphate deaminase (DCTD), and ribonucleotide reductase M1 polypeptide (RRM1) were analyzed with genomic...
متن کاملاکوکاردیوگرافی در تشخیص مایع پریکارد***دکتر علی حدیدی-زری محمدی نیا*
این مقاله فاقد چکیده میباشد.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015